典型文献
Nanobody-based polyvinyl alcohol beads as antifouling adsorbents for selective removal of tumor necrosis factor-α
文献摘要：
Highly efficient removal of tumor necrosis factor-α(TNF-α)from plasma by hemoperfusion for autoim-mune disease therapy remains a challenge in the clinical field owing to the low adsorption capacity and poor blood compatibility of adsorbents.In this work,a new class of nanobody(Nb)-coupled antifouling polyvinyl alcohol(PVA)beads was constructed as an immunosorbent for the selective removal of TNF-αfrom plasma.Notably,our immunosorbent exhibited an exceptionally high specific TNF-α adsorption ca-pacity of 416.9 ng/g in human plasma(at a plasma-to-adsorbent ratio of 300).More importantly,the ob-tained adsorbent beads showed outstanding blood compatibility.In addition,during in vivo experiments,the blood circulation device was constructed to remove TNF-α in rat models,proving that the beads had good removal performance(～85％/60 min).Furthermore,95％of the original capacity was retained after 6-month storage,showed strong stability and prolonged storage of PVA-Nb.Above all,the results indi-cate that the novel PVA-Nb immunosorbent has possible clinical applications for treating autoimmune diseases in the clinic.
文献关键词：
中图分类号：
作者姓名：
Lichun Wang;Yu Ding;Nan Li;Yamin Chai;Qiyu Li;Yunzheng Du;Zhangyong Hong;Lailiang Ou
作者机构：
The key Laboratory of Bioactive Materials,Ministry of Education,College of Life Sciences,Nankai University,Tianjin 300071,China;State Key Laboratory of Medicinal Chemical Biology,Tianjin Key Laboratory of Protein Sciences,College of Life Sciences,Nankai University,Tianjin 300071,China
文献出处：
引用格式：
[1]Lichun Wang;Yu Ding;Nan Li;Yamin Chai;Qiyu Li;Yunzheng Du;Zhangyong Hong;Lailiang Ou-.Nanobody-based polyvinyl alcohol beads as antifouling adsorbents for selective removal of tumor necrosis factor-α)[J].中国化学快报（英文版）,2022(05):2512-2516
A类：
Nanobody
B类：
polyvinyl,alcohol,beads,antifouling,adsorbents,selective,removal,tumor,necrosis,Highly,efficient,from,plasma,by,hemoperfusion,therapy,remains,challenge,clinical,field,owing,low,adsorption,capacity,poor,blood,compatibility,In,this,work,new,class,nanobody,Nb,coupled,PVA,was,constructed,immunosorbent,Notably,our,exhibited,exceptionally,high,specific,human,ratio,More,importantly,showed,outstanding,addition,during,vivo,experiments,circulation,device,remove,models,proving,that,had,good,performance,Furthermore,original,retained,after,month,storage,strong,stability,prolonged,Above,results,indi,cate,novel,has,possible,applications,treating,autoimmune,diseases
AB值：
0.521253
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
