Biomedicine is one of the fastest growing areas of additive manufacturing.Especially,in the field of in vitro diagnostics(IVD),contributions of 3D printing include i)rapid prototyping and iterative IVD proof-of-concept designing ranging from materials,devices to system integration;ii)conceptual design simpli-fication and improved practicality of IVD products;iii)shifting the IVD applications from centralized labs to point-of-care testing(POCT).In this review,the latest developments of 3D printing and its advantages in IVD applications are summarized.A series of 3D-printed objects for IVD applications,including single-function modules,multi-function devices which integrate several single-function modules for specific an-alytical applications such as sample pre-treatment and chemo-/bio-sensing,and all-in-one systems which integrate multi-function devices and the instrument operating them,are analyzed from the perspective of functional integration.The current and potential commercial applications of 3D-printed objects in the IVD field are highlighted.The features of 3D printing,especially rapid prototyping and low start-up,en-able the easy fabrication of bespoke modules,devices and systems for a range of analytical applications,and broadens the commercial IVD prospects.

Jian Yang;Yanxiang Cheng;Xia Gong;Shengzhu Yi;Cheuk-Wing Li;Lelun Jiang;Changqing Yi

Guangdong Provincial Key Laboratory of Sensor Technology and Biomedical Instrument,School of Biomedical Engineering,Sun Yat-sen University,Shenzhen 518107,China;School of Science and Technology,Nottingham Trent University,Clifton Lane,Nottingham NG11 8NS,United Kingdom;Research Institute of Sun Yat-sen University in Shenzhen,Shenzhen 518057,China

中国化学快报（英文版）

[1]Jian Yang;Yanxiang Cheng;Xia Gong;Shengzhu Yi;Cheuk-Wing Li;Lelun Jiang;Changqing Yi-.An integrative review on the applications of 3D printing in the field of in vitro diagnostics)[J].中国化学快报（英文版）,2022(05):2231-2242

Biomedicine,simpli,alytical

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