典型文献
The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii
文献摘要：
Inhibitory Smads (I-Smads), which belong to the Smad family and inhibit bone morphogenic protein 2 (BMP2) signaling by a variety of mechanisms, can suppress innate immunity responses in vertebrates. However, there are no reports for the role of Smad6 in immunity in mollusks. In this study, we showed that Smad6 of the pearl oyster Pinctada fucata martensii was located in the Smad6 cluster of the phylogenetic tree; mRNA expression of Smad6 and Smad3 was up-regulated after lipopolysaccharide and polyinosinic: polycytidylic challenge; and transcript levels of Smad6 and Smad3 showed opposite patterns during wound healing. Under salinity stress, water inflow and outflow in the gills appear to be regulated by BMP2-Smads signals, and BMP2-Smads signaling may be closely related to the immune response. Our results indicate that Smad6 is involved in immunity, that it plays a positive role in the response to immune challenge and an inhibitory role during wound healing, and that Smad6 and Smad3 may work against each other.
文献关键词：
中图分类号：
作者姓名：
Yu SHI;Xiaolan PAN;Meng XU;Huiru LIU;Hanzhi XU;Maoxian HE
作者机构：
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology,Guangdong Provincial Key Laboratory of Applied Marine;Biology,South China Sea Institute of Oceanology,Chinese Academy of Sciences,Guangzhou 510301,China
文献出处：
引用格式：
[1]Yu SHI;Xiaolan PAN;Meng XU;Huiru LIU;Hanzhi XU;Maoxian HE-.The role of Smad6 in immunity of the pearl oyster Pinctada fucata martensii)[J].海洋湖沼学报（英文版）,2022(03):1135-1147
A类：
B类：
role,Smad6,immunity,pearl,oyster,Pinctada,fucata,martensii,Inhibitory,Smads,which,belong,family,bone,morphogenic,protein,BMP2,signaling,by,variety,mechanisms,can,suppress,innate,responses,vertebrates,However,there,are,reports,mollusks,this,study,showed,that,was,located,cluster,phylogenetic,tree,expression,Smad3,regulated,after,lipopolysaccharide,polyinosinic,polycytidylic,challenge,transcript,levels,opposite,patterns,during,wound,healing,Under,salinity,stress,water,inflow,outflow,gills,appear,signals,may,closely,related,immune,Our,results,indicate,involved,plays,positive,inhibitory,work,against,each,other
AB值：
0.527331
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
