The epidermal cell differentiation regulator zinc finger protein 750 (ZNF750) is a transcription factor containing the Cys2His2 (C2H2) domain, the zinc finger structure of which is located at the N-terminal 25–46 amino acids of ZNF750. It can promote the expression of differentiation-related factors while in-hibiting the expression of progenitor cell-related genes. ZNF750 is directly regulated by p63 (encoded by the TP63 gene, belonging to the TP53 superfamily). The Krüppel-like factor 4 (KLF4), repressor element-1 (RE-1)-silencing transcription factor (REST) core-pressor 1 (RCOR1), lysine demethylase 1A (KDM1A), and C-terminal-binding protein 1/2 (CTBP1/2) chro-matin regulators cooperate with ZNF750 to repress epidermal progenitor genes and activate the expres-sion of epidermal terminal differentiation genes (Sen et al., 2012;Boxer et al., 2014). Besides, ZNF750 and the regulatory network composed of bone morphogen?etic protein (BMP) signaling pathway, long non-coding RNAs (lncRNAs) (anti-differentiation non-coding RNA (ANCR) and tissue differentiation-inducing non-protein coding RNA (TINCR)), musculoaponeur?otic fibrosarcoma oncogene (MAF)/MAF family B (MAFB), grainy head-like 3 (GRHL3), and positive regulatory domain zinc finger protein 1 (PRDM1) jointly promote epidermal cell differentiation (Sen et al., 2012).

Lu XIA;Hexin LIN;Yanming ZHOU;Jiabian LIAN

Xiamen Cell Therapy Research Center,the First Affiliated Hospital of Xiamen University,Xiamen 361000,China;Department of Colorectal Surgery,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350004,China;Department of Gastrointestinal Surgery,the First Affiliated Hospital of Xiamen University,Xiamen 361000,China;Department of Clinical Laboratory,the First Affiliated Hospital of Xiamen University,Xiamen 361000,China

浙江大学学报（英文版）（B辑：生物医学和生物技术）

[1]Lu XIA;Hexin LIN;Yanming ZHOU;Jiabian LIAN-.ZNF750 facilitates carcinogenesis via promoting the expression of long non-coding RNA CYTOR and influences pharmacotherapy response in colon adenocarcinoma)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(07):587-596,中插25-中插29

Cys2His2,hibiting,RCOR1,Boxer,TINCR,musculoaponeur

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