典型文献
A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy
文献摘要：
The structural change-medi-ated catalytic activity regulation plays a significant role in the biological functions of natural enzymes.However,there is vir-tually no artificial nanozyme reported that can achieve natural enzyme-like stringent spatiotemporal structure-based catalytic activity regulation.Here,we report a sub-nanostructural transformable gold@ceria(STGC-PEG)nanozyme that performs tun-able catalytic activities via near-infrared(NIR)light-mediated sub-nanostructural transformation.The gold core in STGC-PEG can generate energetic hot electrons upon NIR irradiation,wherein an internal sub-nanostructural transformation is initiated by the conversion between CeO2 and electron-rich state of CeO2-x,and active oxygen vacancies generation via the hot-electron injection.Interestingly,the sub-nanostructural transformation of STGC-PEG enhances peroxidase-like activity and unprecedentedly activates plasmon-promoted oxidase-like activity,allowing highly efficient low-power NIR light(50 mW cm-2)-activated photocatalytic therapy of tumors.Our atomic-level design and fabrication provide a platform to precisely regulate the catalytic activities of nanozymes via a light-mediated sub-nanostructural transformation,approaching natural enzyme-like activity control in complex living systems.
文献关键词：
中图分类号：
作者姓名：
Xi Hu;Nan Wang;Xia Guo;Zeyu Liang;Heng Sun;Hongwei Liao;Fan Xia;Yunan Guan;Jiyoung Lee;Daishun Ling;Fangyuan Li
作者机构：
Institute of Pharmaceutics,Hangzhou Institute of Innovative Medicine,College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,People's Republic of China;Frontiers Science Center for Transformative Molecules,State Key Laboratory of Oncogenes and Related Genes,School of Chemistry and Chemical Engineering,National Center for Translational Medicine,Shanghai Jiao Tong University,Shanghai 200240,People's Republic of China;Department of Clinical Pharmacy,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,People's Republic of China;WLA Laboratories,Shanghai 201203,People's Republic of China;Department of Biomedical-Chemical Engineering,The Catholic University of Korea,43 Jibong-ro,Wonmi-gu,Bucheon-Si,Gyeonggi-do 14662,Republic of Korea
文献出处：
引用格式：
[1]Xi Hu;Nan Wang;Xia Guo;Zeyu Liang;Heng Sun;Hongwei Liao;Fan Xia;Yunan Guan;Jiyoung Lee;Daishun Ling;Fangyuan Li-.A Sub-Nanostructural Transformable Nanozyme for Tumor Photocatalytic Therapy)[J].纳微快报（英文）,2022(06):282-293
A类：
Nanostructural,Transformable,STGC
B类：
Sub,Nanozyme,Tumor,Photocatalytic,Therapy,change,activity,regulation,plays,significant,role,biological,functions,natural,enzymes,However,there,vir,tually,artificial,reported,that,achieve,like,stringent,spatiotemporal,structure,Here,sub,nanostructural,transformable,gold,ceria,PEG,performs,tun,activities,via,near,infrared,NIR,light,mediated,transformation,core,generate,energetic,electrons,upon,irradiation,wherein,internal,initiated,by,conversion,between,CeO2,rich,state,active,oxygen,vacancies,generation,injection,Interestingly,enhances,peroxidase,unprecedentedly,activates,plasmon,promoted,allowing,highly,efficient,power,mW,activated,photocatalytic,therapy,tumors,Our,atomic,level,design,fabrication,provide,platform,precisely,regulate,nanozymes,approaching,control,complex,living,systems
AB值：
0.55632
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