典型文献
Regulating absence seizures by tri-phase delay stimulation applied to globus pallidus internal
文献摘要：
In this paper,a reduced globus pallidus internal(GPI)-corticothalamic(GCT)model is developed,and a tri-phase delay stimulation(TPDS)with sequentially applying three pulses on the GPI representing the inputs from the striatal D1 neurons,subthalamic nucleus(STN),and globus pallidus external(GPE),respectively,is pro-posed.The GPI is evidenced to control absence seizures characterized by 2 Hz-4 Hz spike and wave discharge(SWD).Hence,based on the basal ganglia-thalamocortical(BGCT)model,we firstly explore the triple effects of D1-GPI,GPE-GPI,and STN-GPI pathways on seizure patterns.Then,using the GCT model,we apply the TPDS on the GPI to potentially investigate the alternative and improved approach if these pathways to the GPI are blocked.The results show that the striatum Di,GPE,and STN can indeed jointly and significantly affect seizure patterns.In particular,the TPDS can effectively reproduce the seizure pattern if the D1-GPI,GPE-GPI,and STN-GPI pathways are cut off.In addition,the seizure abatement can be obtained by well tuning the TPDS stimu-lation parameters.This implies that the TPDS can play the surrogate role similar to the modulation of basal ganglia,which hopefully can be helpful for the development of the brain-computer interface in the clinical application of epilepsy.
文献关键词：
中图分类号：
作者姓名：
Songan HOU;Denggui FAN;Qingyun WANG
作者机构：
Department of Dynamics and Control,Beihang University,Beijing 100191,China;School of Mathematics and Physics,University of Science and Technology Beijing,Beijing 100083,China;Beijing Institute of Brain Disorders,Capital Medical University,Beijing 100069,China
文献出处：
引用格式：
[1]Songan HOU;Denggui FAN;Qingyun WANG-.Regulating absence seizures by tri-phase delay stimulation applied to globus pallidus internal)[J].应用数学和力学（英文版）,2022(09):1399-1414
A类：
corticothalamic,thalamocortical,BGCT
B类：
Regulating,absence,seizures,by,phase,delay,stimulation,applied,globus,pallidus,internal,In,this,paper,reduced,GPI,model,developed,TPDS,sequentially,applying,three,pulses,representing,inputs,from,striatal,D1,neurons,subthalamic,nucleus,STN,external,GPE,respectively,posed,evidenced,control,characterized,spike,wave,discharge,SWD,Hence,basal,ganglia,firstly,explore,triple,effects,pathways,patterns,Then,using,potentially,investigate,alternative,improved,approach,these,are,blocked,results,show,that,striatum,Di,indeed,jointly,significantly,affect,particular,effectively,reproduce,cut,off,addition,abatement,be,obtained,well,tuning,parameters,This,implies,play,surrogate,role,similar,modulation,which,hopefully,helpful,development,brain,computer,interface,clinical,application,epilepsy
AB值：
0.480114
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
