典型文献
Enhanced bioavailability and biosafety of cannabidiol nanomicelles for effective anti-inflammatory therapy
文献摘要：
Cannabidiol(CBD)shows great anti-inflammatory potential;however,the hydrophobicity and strong first-pass effect of CBD leads to its extremely low oral bioavailability.Poloxamer 407(P407)is a tri-block copolymer composed of(poly)ethylene oxide(PEO)and(poly)propylene oxide(PPO)sections.It has a PEO-PPO-PEO structure,which is widely used in the preparation of drug delivery systems that are highly biocompatible.When it reaches a certain concentration in water,P407 can self-assemble into a micelle structure containing a hydrophobic core and a hydrophilic shell.A potential approach to enhanc-ing the oral bioavailability of hydrophobic drugs incorporating them into the hydrophilic carrier.We prepared CBD nanomicelles with a drug loading of 14.29％by a cosolvent evaporation method using P407 with appropriate antioxidants.Cell experiments indicated that anti-inflammatory markers(IL-4 and IL-10)increased,while inflammatory markers(TNF-α and IL-6)decreased.Moreover,animal experiments showed that inflammatory cells were inhibited by CBD nanomicelles,and the anti-inflammatory effect of micelles was better than that of CBD,while no obvious evidence indicated toxicity to the liver and kidney.
文献关键词：
中图分类号：
作者姓名：
Yuan Rao;Runwei Li;Saixing Liu;Linchao Meng;Qilin Wu;Qipeng Yuan;Hao Liang;Meng Qin
作者机构：
College of Life Science and Technology,Beijing University of Chemical Technology,Beijing 100029,China;StarHealth Botanical Technology Corporation,Beijing 100005,China
文献出处：
引用格式：
[1]Yuan Rao;Runwei Li;Saixing Liu;Linchao Meng;Qilin Wu;Qipeng Yuan;Hao Liang;Meng Qin-.Enhanced bioavailability and biosafety of cannabidiol nanomicelles for effective anti-inflammatory therapy)[J].颗粒学报（英文版）,2022(10):1-9
A类：
cosolvent
B类：
Enhanced,bioavailability,biosafety,cannabidiol,nanomicelles,effective,inflammatory,therapy,Cannabidiol,CBD,shows,great,potential,however,hydrophobicity,strong,first,pass,leads,its,extremely,low,oral,Poloxamer,P407,is,tri,block,copolymer,composed,ethylene,oxide,PEO,propylene,PPO,sections,It,has,structure,which,widely,used,preparation,delivery,systems,that,highly,biocompatible,When,reaches,certain,concentration,water,self,assemble,into,containing,core,hydrophilic,shell,approach,enhanc,drugs,incorporating,them,carrier,We,prepared,loading,by,evaporation,method,using,appropriate,antioxidants,Cell,experiments,indicated,markers,increased,while,decreased,Moreover,animal,showed,cells,were,inhibited,was,better,than,obvious,evidence,toxicity,kidney
AB值：
0.578515
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
