典型文献
E2F4 regulates the cell cycle and DNA replication in the silkworm,Bombyx mori
文献摘要：
The E2F family of transcription factors is crucial for cell cycle progression and cell fate decisions.Although E2Fs have been widely studied in mammals,there have been few studies performed in insects.Here,we determined the function of E2F4 in the silkworm,Bombyx mori.We demonstrate that E2F proteins are highly conserved among species from lower animals to higher mammals.Overexpression of the BmE2F4 gene led to cell cycle arrest in the G1 phase,whereas interfering with the BmE2F4 mRNA led to ac-cumulation of cells in the S phase.These results indicate that BmE2F4 is important in cell cycle regulation.We also demonstrate that the BmE2F4 gene is involved in DNA replica-tion of BmN-SWU1 cells and DNA synthesis in the silk gland.Furthermore,we identified a protein called Bm14-3-3ζ that can interact with BmE2F4 and allow it to localize in the nucleus.Overexpression of the Bm14-3-3ζ gene led to cell cycle arrest in the G1 phase,while knocking down the gene increased the proportion of cells in S phase.These findings provide important insights into the function of E2F transcription factors and increase our understanding of their involvement in cell cycle regulation.
文献关键词：
中图分类号：
作者姓名：
Peng Chen;Ling Wang;Yan-Bi Long;Guang-Yan Liang;Xiu Yang;Zhan-Qi Dong;Xia Jiang;Yan Zhu;Min-Hui Pan;Cheng Lu
作者机构：
State Key Laboratory of Silkworm Genome Biology,Southwest University,Chongqing,China;Key Laboratory of Sericultural Biology and Genetic Breeding,Ministry of Agriculture and Rural Affairs,Southwest University,Chongqing,China
文献出处：
引用格式：
[1]Peng Chen;Ling Wang;Yan-Bi Long;Guang-Yan Liang;Xiu Yang;Zhan-Qi Dong;Xia Jiang;Yan Zhu;Min-Hui Pan;Cheng Lu-.E2F4 regulates the cell cycle and DNA replication in the silkworm,Bombyx mori)[J].中国昆虫科学（英文版）,2022(04):1006-1016
A类：
E2Fs,BmE2F4,Bm14
B类：
regulates,cycle,replication,silkworm,Bombyx,mori,family,transcription,factors,crucial,progression,fate,decisions,Although,have,been,widely,studied,mammals,there,few,studies,performed,insects,Here,determined,function,We,demonstrate,that,proteins,are,highly,conserved,among,species,from,lower,animals,higher,Overexpression,gene,arrest,G1,phase,whereas,interfering,cumulation,cells,These,results,indicate,important,regulation,also,involved,BmN,SWU1,synthesis,gland,Furthermore,identified,called,can,interact,allow,localize,nucleus,while,knocking,down,increased,proportion,findings,provide,insights,into,our,understanding,their,involvement
AB值：
0.455487
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