典型文献
SMIP-30,a potent and selective PPM1A inhibitor with potential to treat tuberculosis
文献摘要：
Recently,a collaborative research led by Weibo Yang and Jim Sun1 published in Cell Chemical Biology identified a potent and selective small molecule inhibitor(SMIP-30)for human protein phosphatase Mg2+/Mn2+-dependent 1 A(PPM1A).They applied this chemical probe to determine the autophagy receptor p62 as a new substrate of PPM1A,and proved that SMIP-30 could enhance the selective autophagy of macrophages to limit the survival of intracellular Mycobacterium tuberculosis(Mtb)(Fig.1).These findings should promote new therapeutic modalities to overcome tuberculosis(TB)1.
文献关键词：
中图分类号：
作者姓名：
Shujing Xu;Xinyong Liu;Peng Zhan
作者机构：
Department of Medicinal Chemistry,Key Laboratory of Chemical Biology,Ministry of Education,School of Pharmaceutical Sciences,Shandong University,Ji'nan 250012,China
文献出处：
引用格式：
[1]Shujing Xu;Xinyong Liu;Peng Zhan-.SMIP-30,a potent and selective PPM1A inhibitor with potential to treat tuberculosis)[J].药学学报（英文版）,2022(12):4519-4521
A类：
SMIP,PPM1A,Sun1
B类：
selective,inhibitor,potential,treat,tuberculosis,Recently,collaborative,research,led,by,Weibo,Yang,Jim,published,Cell,Chemical,Biology,identified,small,molecule,human,protein,phosphatase,Mg2+,Mn2+,dependent,They,applied,this,chemical,probe,determine,autophagy,receptor,p62,new,substrate,proved,that,could,enhance,macrophages,limit,survival,intracellular,Mycobacterium,Mtb,Fig,These,findings,should,promote,therapeutic,modalities,overcome,TB
AB值：
0.632623
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
