典型文献
Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability
文献摘要：
Tumor cells have unique metabolic programming that is biologically distinct from that of corresponding normal cells.Resetting tumor metabolic programming is a promising strategy to amelio-rate drug resistance and improve the tumor microenvironment.Here,we show that carboxyamidotriazole(CAI),an anticancer drug,can function as a metabolic modulator that decreases glucose and lipid meta-bolism and increases the dependency of colon cancer cells on glutamine metabolism.CAI suppressed glucose and lipid metabolism utilization,causing inhibition of mitochondrial respiratory chain complex I,thus producing reactive oxygen species(ROS).In parallel,activation of the aryl hydrocarbon receptor(AhR)increased glutamine uptake via the transporter SLC1A5,which could activate the ROS-scavenging enzyme glutathione peroxidase.As a result,combined use of inhibitors of GLS/GDH1,CAI could effectively restrict colorectal cancer(CRC)energy metabolism.These data illuminate a new antitumor mechanism of CAI,suggesting a new strategy for CRC metabolic reprogramming treatment.
文献关键词：
中图分类号：
作者姓名：
Jing Shi;Rui Ju;Hongting Gao;Yuqing Huang;Lei Guo;Dechang Zhang
作者机构：
Department of Pharmacology,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences and School of Basic Medicine,Peking Union Medical College,Beijing 100005,China;Department of Pharmacy,Peking University Third Hospital,Beijing 100191,China
文献出处：
引用格式：
[1]Jing Shi;Rui Ju;Hongting Gao;Yuqing Huang;Lei Guo;Dechang Zhang-.Targeting glutamine utilization to block metabolic adaptation of tumor cells under the stress of carboxyamidotriazole-induced nutrients unavailability)[J].药学学报（英文版）,2022(02):759-773
A类：
carboxyamidotriazole,Resetting,GDH1
B类：
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AB值：
0.628168
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