典型文献
Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis
文献摘要：
Aging-elevated DNMT3A R882H-driven clonal hematopoiesis(CH)is a risk factor for myeloid malignancies remission and overall survival.Although some studies were conducted to investi-gate this phenomenon,the exact mechanism is still under debate.In this study,we observed that DNMT3A R878H bone marrow cells(human allele:DNMT3A R882H)displayed enhanced reconstitu-tion capacity in aged bone marrow milieu and upon inflammatory insult.DNMT3A R878H protects he-matopoietic stem and progenitor cells from the damage induced by chronic inflammation,especially TNFα insults.Mechanistically,we identified that RIPK1-RIPK3-MLKL-mediated necroptosis signaling was compromised in R878H cells in response to proliferation stress and TNFα insults.Briefly,we elucidated the molecular mechanism driving DNMT3A R878H-based clonal hematopoiesis,which raises clinical value for treating DNMT3A R882H-driven clonal hematopoiesis and myeloid malig-nancies with aging.
文献关键词：
中图分类号：
作者姓名：
Min Liao;Ruiqing Chen;Yang Yang;Hanqing He;Liqian Xu;Yuxuan Jiang;Zhenxing Guo;Wei He;Hong Jiang;Jianwei Wang
作者机构：
School of Pharmaceutical Sciences,Tsinghua University,Beijing 100084,China;Department of Hematology/Oncology,First Hospital of Tsinghua University,Beijing 100016,China;Kidney Disease Center,the First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,China
文献出处：
引用格式：
[1]Min Liao;Ruiqing Chen;Yang Yang;Hanqing He;Liqian Xu;Yuxuan Jiang;Zhenxing Guo;Wei He;Hong Jiang;Jianwei Wang-.Aging-elevated inflammation promotes DNMT3A R878H-driven clonal hematopoiesis)[J].药学学报（英文版）,2022(02):678-691
A类：
R878H,R882H,reconstitu,matopoietic,nancies
B类：
Aging,elevated,inflammation,promotes,DNMT3A,driven,clonal,hematopoiesis,CH,risk,myeloid,malignancies,remission,overall,survival,Although,some,studies,were,conducted,investi,gate,this,phenomenon,exact,mechanism,still,under,debate,In,study,observed,that,bone,marrow,cells,human,allele,displayed,enhanced,capacity,aged,milieu,upon,inflammatory,protects,stem,progenitor,from,damage,induced,by,chronic,especially,insults,Mechanistically,identified,RIPK1,RIPK3,MLKL,mediated,necroptosis,signaling,was,compromised,response,proliferation,stress,Briefly,elucidated,molecular,driving,which,raises,clinical,value,treating,aging
AB值：
0.521908
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
