典型文献
Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy
文献摘要：
Chimeric antigen receptor T cell(CART)therapy was a milestone in the treatment of relapsed and refractory B cell malignancies.However,beneficial effects of CAR T cells have not been obtained in solid tumors yet.Herein,we implement a porous microneedle patch that accommodates CAR T cells and allows in situ penetration-mediated seeding of CAR T cells when implanted in the tumor bed or in the post-surgical resection cavity.CAR T cells loaded in the pores of the microneedle tips were readily escorted to the tumor in an evenly scattered manner without losing their activity.Such microneedle-mediated local delivery enhanced infiltration and immunostimulation of CART cells as compared to direct intratumoral injection.This tailorable patch offers a transformative platform for scattered seeding of living cells for treating a variety of tumors.
文献关键词：
中图分类号：
作者姓名：
Hongjun Li;Zejun Wang;Edikan A.Ogunnaike;Qing Wu;Guojun Chen;Quanyin Hu;Tianyuan Ci;Zhaowei Chen;Jinqiang Wang;Di Wen;Hongwei Du;Jie Jiang;Jie Sun;Xingcai Zhang;Gianpietro Dotti;Zhen Gu
作者机构：
College of Pharmaceutical Sciences,Zhejiang University,Hangzhou 310058,China;Liangzhu Laboratory,Zhejiang University Medical Center,Hangzhou 310058,China;Department of Bioengineering,University of California,Los Angeles,CA 90095,USA;Jonsson Comprehensive Cancer Center,University of California,Los Angeles,CA 90095,USA;California NanoSystems Institute,University of California,Los Angeles,CA 90095,USA;Center for Nanotechnology in Drug Delivery,Eshelman School of Pharmacy,University of North Carolina,Chapel Hill,NC 27599,USA;Lineberger Comprehensive Cancer Center,University of North Carolina,Chapel Hill,NC 27599,USA;Joint Department of Biomedical Engineering,University of North Carolina at Chapel Hill and North Carolina State University,Raleigh,NC 27695,USA;Department of Microbiology and Immunology,University of North Carolina,Chapel Hill,NC 27599 USA;Department of Cell Biology and Bone Marrow Transplantation Center of the First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China;John A Paulson School of Engineering and Applied Sciences,Harvard University,Cambridge,MA 02138,USA;Department of General Surgery,Sir Run Run Shaw Hospital,School of Medicine,Zhejiang University,Hangzhou 310016,China
文献出处：
引用格式：
[1]Hongjun Li;Zejun Wang;Edikan A.Ogunnaike;Qing Wu;Guojun Chen;Quanyin Hu;Tianyuan Ci;Zhaowei Chen;Jinqiang Wang;Di Wen;Hongwei Du;Jie Jiang;Jie Sun;Xingcai Zhang;Gianpietro Dotti;Zhen Gu-.Scattered seeding of CAR T cells in solid tumors augments anticancer efficacy)[J].国家科学评论（英文版）,2022(03):38-47
A类：
escorted,immunostimulation
B类：
Scattered,seeding,cells,solid,tumors,augments,anticancer,efficacy,Chimeric,antigen,receptor,CART,therapy,was,milestone,treatment,relapsed,refractory,malignancies,However,beneficial,effects,have,not,been,obtained,yet,Herein,implement,porous,microneedle,patch,that,accommodates,allows,situ,penetration,mediated,when,implanted,bed,post,surgical,resection,cavity,loaded,pores,tips,were,readily,evenly,scattered,manner,without,losing,their,activity,Such,local,delivery,enhanced,infiltration,compared,direct,intratumoral,injection,This,tailorable,offers,transformative,platform,living,treating,variety
AB值：
0.645914
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