典型文献
dbDEMC 3.0:Functional Exploration of Differentially Expressed miRNAs in Cancers of Human and Model Organisms
文献摘要：
MicroRNAs(miRNAs)are important regulators in gene expression.The dysregulation of miRNA expression is widely reported in the transformation from physiological to pathological states of cells.A large number of differentially expressed miRNAs(DEMs)have been identified in various human cancers by using high-throughput technologies,such as microarray and miRNA-seq.Through mining of published studies with high-throughput experiment information,the data-base of DEMs in human cancers(dbDEMC)was constructed with the aim of providing a systematic resource for the storage and query of the DEMs.Here we report an update of the dbDEMC to version 3.0,which contains two-fold more data entries than the second version and now includes also data from mice and rats.The dbDEMC 3.0 contains 3268 unique DEMs in 40 different cancer types.The current datasets for differential expression analysis have expanded to 9 generalized cat-egories.Moreover,the current release integrates functional annotations of DEMs obtained by using experimentally validated targets.The annotations can be of great benefit to the intensive analysis of the roles of DEMs in cancer.In summary,dbDEMC 3.0 provides a valuable resource for charac-terizing molecular functions and regulatory mechanisms of DEMs in human cancers.
文献关键词：
中图分类号：
作者姓名：
Feng Xu;Yifan Wang;Yunchao Ling;Chenfen Zhou;Haizhou Wang;Andrew E.Teschendorff;Yi Zhao;Haitao Zhao;Yungang He;Guoqing Zhang;Zhen Yang
作者机构：
Center for Medical Research and Innovation of Pudong Hospital,Fudan University Pudong Medical Center,Shanghai 201399,China;Institutes of Biomedical Science,Shanghai Key Laboratory of Medical Epigenetics,International Co-laboratory of Medical Epigenetics and Metabolism(Ministry of Science and Technology),Fudan University,Shanghai 200032,China;Bio-Med Big Data Center,CAS Key Laboratory of Computational Biology,Shanghai Institute of Nutrition and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China;CAS Key Laboratory of Computational Biology,Shanghai Institute of Nutrition and Health,University of Chinese Academy of Sciences,Chinese Academy of Sciences,Shanghai 200031,China;Institute of Computing Technology,Chinese Academy of Sciences,Beijing 100190,China;Department of Liver Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;Shanghai Fifth People,s Hospital,Fudan University,Shanghai 200240,China
文献出处：
引用格式：
[1]Feng Xu;Yifan Wang;Yunchao Ling;Chenfen Zhou;Haizhou Wang;Andrew E.Teschendorff;Yi Zhao;Haitao Zhao;Yungang He;Guoqing Zhang;Zhen Yang-.dbDEMC 3.0:Functional Exploration of Differentially Expressed miRNAs in Cancers of Human and Model Organisms)[J].基因组蛋白质组与生物信息学报（英文版）,2022(03):446-454
A类：
dbDEMC
B类：
Functional,Exploration,Differentially,Expressed,miRNAs,Cancers,Human,Model,Organisms,MicroRNAs,are,important,regulators,expression,dysregulation,widely,reported,transformation,from,physiological,pathological,states,cells,large,number,differentially,expressed,DEMs,have,been,identified,various,human,cancers,by,using,high,throughput,technologies,such,microarray,seq,Through,mining,published,studies,information,base,was,constructed,aim,providing,systematic,resource,storage,query,Here,we,update,version,which,contains,two,fold,more,entries,than,second,now,includes,also,mice,rats,unique,types,current,datasets,analysis,expanded,generalized,cat,egories,Moreover,release,integrates,functional,annotations,obtained,experimentally,validated,targets,great,benefit,intensive,roles,In,summary,provides,valuable,charac,terizing,molecular,functions,regulatory,mechanisms
AB值：
0.593955
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