典型文献
Programmed death 1 (PD-1) and ligand (PD-L1) inhibitors in head and neck squamous cell carcinoma: A meta-analysis
文献摘要：
Background::PD-1 and PD-L1 inhibitors have emerged as promising treatments for patients with head and neck squamous cell carcinoma (HNSCC).Methods::Systematic review and meta-analysis of PD-1 and PD-L1 inhibitors in HNSCC. Outcomes: median overall survival (mOS), median progression-free survival (mPFS), Response Evaluation Criteria in Solid Tumors (RECIST) and treatment-related adverse events (TRAEs).Results::Eleven trials reported data on 1088 patients (mean age: 59.9 years, range: 18-90). The total mOS was 7.97 months (range: 6.0-16.5). Mean mPFS for all studies was 2.84 months (range: 1.9-6.5). PD-1 inhibitors had a lower rate of RECIST Progressive Disease than PD-L1 inhibitors (42.61%, 95% confidence interval [CI]: 36.29-49.06 vs. 56.79%, 95% CI: 49.18-64.19,
P < 0.001). The rate of TRAEs of any grade (62.7%, 95% CI: 59.8-65.6) did not differ.
Conclusions::Meta-analysis shows the efficacy of PD-1 and PD-L1 inhibitors in HNSCC and suggests a possible difference in certain RECIST criterion between PD-1 and PD-L1 inhibitors. Future work to investigate the clinical significance of these findings is warranted.
文献关键词：
antibodies;disease progression;head and neck neoplasms;humanized;meta-analysis;monoclonal;squamous cell carcinoma of the neck
中图分类号：
作者姓名：
Levy Dylan A.;Patel Jaimin J.;Nguyen Shaun A.;Jungbauer W. Nicholas;Neskey David M.;Cohen Ezra E. W.;Paulos Chrystal M.;Kaczmar John A.;Knochelmann Hannah M.;Day Terry A.
作者机构：
Department of Otolaryngology-Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA;Department of Cell and Molecular Pharmacology and Developmental Therapeutics, Medical University of South Carolina, Charleston, South Carolina, USA;Department of Medicine, Division of Hematology-Oncology, University of California, San Diego, La Jolla, California, USA;Department of Microbiology and Immunology, Medical University of South Carolina, Charleston, South Carolina, USA;Department of Dermatology and Dermatologic Surgery, Medical University of South Carolina, Charleston, South Carolina, USA;Division of Hematology & Oncology, Medical University of South Carolina, Charleston, South Carolina, USA
文献出处：
引用格式：
[1]Levy Dylan A.;Patel Jaimin J.;Nguyen Shaun A.;Jungbauer W. Nicholas;Neskey David M.;Cohen Ezra E. W.;Paulos Chrystal M.;Kaczmar John A.;Knochelmann Hannah M.;Day Terry A.-.Programmed death 1 (PD-1) and ligand (PD-L1) inhibitors in head and neck squamous cell carcinoma: A meta-analysis)[J].世界耳鼻咽喉头颈外科杂志（英文）,2022(03):177-186
A类：
TRAEs
B类：
Programmed,death,ligand,L1,inhibitors,head,neck,squamous,cell,carcinoma,meta,analysis,Background,have,emerged,promising,treatments,patients,HNSCC,Methods,Systematic,review,Outcomes,median,overall,survival,mOS,progression,free,mPFS,Response,Evaluation,Criteria,Solid,Tumors,RECIST,related,adverse,events,Results,Eleven,trials,reported,data,mean,age,years,range,total,was,months,Mean,studies,had,lower,rate,Progressive,Disease,than,confidence,interval,any,grade,did,not,Conclusions,shows,efficacy,suggests,possible,difference,certain,criterion,between,Future,work,investigate,clinical,significance,these,findings,warranted,antibodies,disease,neoplasms,humanized,monoclonal
AB值：
0.554097
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