典型文献
Effect of N-acetyl-cysteine treatment on sensorineural hearing loss: a meta-analysis
文献摘要：
N-acetyl-cysteine (NAC) is an efficacious treatment for sensorineural hearing loss in animal models, such as noise-induced hearing loss (NIHL), however previous research into the effect of NAC on patients with hearing loss produced contradictory results. In this study, we investigated the effect of NAC treatment on sensorineural hearing loss. PubMed, Web of Science and Embase databases were searched in their entirety using the key words: hearing loss, NAC, N-acetylcysteine, and sensorineural hearing loss. Studies which included assessment of hearing loss with pure-tone threshold (PTA) data were selected. Eligible studies regarding the effects of NAC treatment on patients with hearing loss were collected by two independent reviewers. A total of 1197 individuals were included from seven published studies. Two studies reported data for a sudden idiopathic sensorineural hearing loss (SISNHL) group. Three studies reported data for a NIHL group. Other studies reported data for drug-induced hearing loss. The meta-analysis demonstrated that the overall effect of NAC treatment on sensorineural hearing loss was invalid. However, NAC treatment was linked with improved patient outcomes of hearing tests in cases of sudden hearing loss, but did not prevent hearing loss induced by noise or ototoxicity. However, there is a need for better-designed studies with larger samples to further prove the correlation between the effect of NAC and hearing loss.
文献关键词：
Hearing loss;Meta-analysis;N-acetyl-cysteine
中图分类号：
作者姓名：
Bai Xue;Wang Miao;Niu Xun;Yu Hong;Yue Jian-Xin;Sun Yu
作者机构：
Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China
文献出处：
引用格式：
[1]Bai Xue;Wang Miao;Niu Xun;Yu Hong;Yue Jian-Xin;Sun Yu-.Effect of N-acetyl-cysteine treatment on sensorineural hearing loss: a meta-analysis)[J].世界耳鼻咽喉头颈外科杂志（英文）,2022(03):205-212
A类：
SISNHL
B类：
Effect,treatment,sensorineural,hearing,loss,meta,analysis,NAC,efficacious,animal,models,such,noise,induced,NIHL,however,previous,research,into,patients,produced,contradictory,results,In,this,study,investigated,Embase,databases,were,searched,their,entirety,using,key,words,acetylcysteine,Studies,which,included,assessment,pure,tone,threshold,PTA,selected,Eligible,studies,regarding,effects,collected,by,two,independent,reviewers,total,individuals,from,seven,published,Two,reported,sudden,idiopathic,group,Three,Other,drug,demonstrated,that,overall,was,invalid,However,linked,improved,outcomes,tests,cases,but,did,not,prevent,ototoxicity,there,need,better,designed,larger,samples,further,correlation,between,Hearing
AB值：
0.448119
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