典型文献
Fungal periprosthetic joint infection: Rare but challenging problem
文献摘要：
Periprosthetic joint infection (PJI) is the most difficult complication following total joint arthroplasty. Most of the etiological strains, accounting for over 98% of PJI, are bacterial species, with
Staphylococcus aureus and
Coagulase-negative staphylococci present in between 50% and 60% of all PJIs. Fungi, though rare, can also cause PJI in 1%—2% of cases and can be challenging to manage. The management of this uncommon but complex condition is challenging due to the absence of a consistent algorithm. Diagnosis of fungal PJI is difficult as isolation of the organisms by traditional culture may take a long time, and some of the culture-negative PJI can be caused by fungal organisms. In recent years, the introduction of next-generation sequencing has provided opportunity for isolation of the infective organisms in culture-negative PJI cases. The suggested treatment is based on consensus and includes operative and non-operative measures. Two-stage revision surgery is the most reliable surgical option for chronic PJI caused by fungi. Pharmacological therapy with antifungal agents is required for a long period of time with antibiotics and included to cover superinfections with bacterial species. The aim of this review article is to report the most up-to-date information on the diagnosis and treatment of fungal PJI with the intention of providing clear guidance to clinicians, researchers and surgeons.
文献关键词：
Fungi;Periprosthetic joint infection;Diagnosis and treatment
中图分类号：
作者姓名：
Chisari Emanuele;Lin Feitai;Fei Jun;Parvizi Javad
作者机构：
Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, 19107, USA;Department of Emergency Medicine of Army Medical Center, Army Medical University, Chongqing, 400042, China;State Key Laboratory of Trauma, Burns and Combined Injury, Army Medical University, Chongqing, 400042, China
文献出处：
引用格式：
[1]Chisari Emanuele;Lin Feitai;Fei Jun;Parvizi Javad-.Fungal periprosthetic joint infection: Rare but challenging problem)[J].中华创伤杂志（英文版）,2022(02):63-66
A类：
Periprosthetic,Coagulase,PJIs,superinfections
B类：
Fungal,periprosthetic,joint,Rare,but,challenging,problem,most,difficult,complication,following,total,arthroplasty,Most,etiological,strains,accounting,bacterial,species,Staphylococcus,aureus,negative,staphylococci,present,between,Fungi,though,rare,can,also,cases,management,this,uncommon,complex,condition,due,absence,consistent,algorithm,Diagnosis,isolation,organisms,by,traditional,culture,may,take,long,some,caused,In,recent,years,introduction,next,generation,sequencing,has,provided,opportunity,infective,suggested,treatment,consensus,includes,operative,measures,Two,stage,revision,surgery,reliable,surgical,option,chronic,fungi,Pharmacological,therapy,antifungal,agents,required,period,antibiotics,included,cover,aim,review,article,report,date,information,diagnosis,intention,providing,clear,guidance,clinicians,researchers,surgeons
AB值：
0.509995
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
