典型文献
Radical SAM-Dependent Demetallation of Heme
文献摘要：
Demetallation of heme to release iron is a chemical difficult reaction and is highly rare in biochemistry,with apoferritin as the only known enzyme responsible for this process.Here we show the heme degradation enzyme ChuW catalyzes heme demetallation be-sides its known methyltransferase activity(which converts heme to a ring-open product anaerobilin).We show the demetallation ac-tivity of ChuW is radical SAM-dependent,and likely involves the same set of intermediates involved in the anaerobilin-producing pathway.The ChuW-catalyzed demetallation reaction does not require external reductant,and can occur on several heme analogs with different metal centers.These findings establish a brand-new chemistry in the radical SAM enzymes,highlighting the remarka-ble catalytic diversity of this superfamily of enzymes.
文献关键词：
中图分类号：
作者姓名：
Jinduo Cheng;Wei Ding;Qi Zhang
作者机构：
Department of Chemistry,Fudan University,Shanghai 200433,China;State Key Laboratory of Microbial Metabolism,School of Life Sciences&Biotechnology,Shanghai Jiao Tong University,Shanghai 200240,China
文献出处：
引用格式：
[1]Jinduo Cheng;Wei Ding;Qi Zhang-.Radical SAM-Dependent Demetallation of Heme)[J].中国化学（英文版）,2022(09):1053-1058
A类：
Demetallation,apoferritin,ChuW,demetallation,anaerobilin,remarka
B类：
Radical,SAM,Dependent,Heme,heme,release,iron,chemical,difficult,reaction,highly,rare,biochemistry,only,known,responsible,this,process,Here,we,show,degradation,catalyzes,be,sides,its,methyltransferase,activity,which,converts,ring,open,product,We,radical,dependent,likely,involves,same,set,intermediates,involved,producing,pathway,catalyzed,does,not,require,external,reductant,can,occur,several,analogs,different,centers,These,findings,establish,brand,new,enzymes,highlighting,catalytic,diversity,superfamily
AB值：
0.530671
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