典型文献
Hybeanones A and B,Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii
文献摘要：
Hybeanones A and B (1 and 2),two highly oxygenated and rearranged polycyclic polyprenylated acylphloroglucinols (PPAPs),were isolated from the aerial parts of Hypericum beanii.Their structures comprising absolute configurations were elucidated by spectro-scopic analysis,single-crystal X-ray diffraction,and quantum chemical calculations.Compounds 1.and 2 are defined by a newly as-sembled cyclopentanone unit fused to a tricyclic γ-lactone unit via a ketone carbonyl.The breakage of C-1/C-2 linkage via ret-ro-Claisen reaction,attack from C-1 to C-19,and Baeyer-Villiger oxidation at C-1/C-23 bond were presumed to be the key steps in the assembly of 1 and 2.The isolates 1 and 2 showed potential acetylcholinesterase (AchE) inhibitory activities,with ICs0 values of 21.34± 1.48 and 18.79 ±2.36 μmol/L,respectively.
文献关键词：
中图分类号：
作者姓名：
Beiye Yang;Changxing Qi;Zeyu Yao;Shuang Lin;Fengli Li;Weiguang Sun;Zhengxi Hu;Yonghui Zhang
作者机构：
Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation,School of Pharmacy,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430030,China
文献出处：
引用格式：
[1]Beiye Yang;Changxing Qi;Zeyu Yao;Shuang Lin;Fengli Li;Weiguang Sun;Zhengxi Hu;Yonghui Zhang-.Hybeanones A and B,Two Highly Modified Polycyclic Polyprenylated Acylphloroglucinols from Hypericum beanii)[J].中国化学（英文版）,2022(01):53-58
A类：
Hybeanones,Polyprenylated,Acylphloroglucinols,beanii,polyprenylated,acylphloroglucinols,PPAPs,sembled,cyclopentanone
B类：
Two,Highly,Modified,Polycyclic,from,Hypericum,two,highly,oxygenated,rearranged,polycyclic,were,isolated,aerial,parts,Their,structures,comprising,absolute,configurations,elucidated,by,spectro,scopic,analysis,single,crystal,ray,diffraction,quantum,chemical,calculations,Compounds,are,defined,newly,unit,fused,tricyclic,lactone,via,ketone,carbonyl,breakage,linkage,ret,Claisen,reaction,attack,Baeyer,Villiger,oxidation,bond,presumed,key,steps,assembly,isolates,showed,potential,acetylcholinesterase,AchE,inhibitory,activities,ICs0,values,respectively
AB值：
0.63971
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