典型文献
Continuous deacylation of amides in a high-temperature and high-pressure microreactor
文献摘要：
The deacylation of amides,which is widely employed in the pharmaceutical industry,is not a fast reaction under normal conditions.To intensify this reaction,a high-temperature and high-pressure continuous microreaction technology was developed,whose space-time yield was 49.4 times that of traditional batch reactions.Using the deacylation of acetanilide as a model reaction,the effects of the temperature,pressure,reaction time,molar ratio of reactants,and water composition on acetanilide conversion were carefully studied.Based on the rapid heating and cooling capabilities,the kinetics of acetanilide deacylation at high temperatures were investigated to determine the orders of reactants and activation energy.This microreaction technology was further applied to a variety of other amides to understand the influence of substituents and steric hindrance on the deacylation reaction.
文献关键词：
中图分类号：
作者姓名：
Pengcheng Zou;Kai Wang;Guangsheng Luo
作者机构：
State Key Lab of Chemical Engineering,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China
文献出处：
引用格式：
[1]Pengcheng Zou;Kai Wang;Guangsheng Luo-.Continuous deacylation of amides in a high-temperature and high-pressure microreactor)[J].化学科学与工程前沿,2022(12):1818-1825
A类：
deacylation,microreaction,acetanilide
B类：
Continuous,amides,high,pressure,microreactor,which,widely,employed,pharmaceutical,industry,not,fast,normal,conditions,To,intensify,this,continuous,technology,was,developed,whose,space,yield,times,that,traditional,batch,reactions,Using,model,effects,molar,ratio,reactants,water,composition,conversion,were,carefully,studied,Based,rapid,heating,cooling,capabilities,kinetics,temperatures,investigated,determine,orders,activation,energy,This,further,applied,variety,other,understand,influence,substituents,steric,hindrance
AB值：
0.514217
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