典型文献
Nitric oxide-generating self-assembling peptide hydrogel coating for enhancing hemocompatibility of blood-contacting devices
文献摘要：
Thrombosis is the major stumbling block to the clinical application of blood-contacting devices.Herein,a quick and easy surface engineering strategy of hydrogel coating with the therapeutic gas nitric oxide(NO)generation was reported to realize up-regulation of cyclic guanosine monophosphate(cGMP)and improve hemocompatibility for diverse metal materials.We first introduce the active centre selenocys-teine of glutathione peroxidase(GPx)to the self-assembling peptide(RADA)4,obtaining a functionalized hydrogel.Then the hydrogel is directly coated on the 316L stainless steel(SS)for catalytically generating NO from endogenous s-nitrosothiols(RSNO).The generated NO endows the coated surface with regula-tion of platelet behavior and reduction of plasmatic coagulation activation and complement system acti-vation,hence improving antithrombotic ability in vitro and ex vivo.Overall,our NO-generating hydrogel coating surface engineering strategy provides a novel solution to remove the obstacle about thrombosis of blood-contacting devices in clinic.
文献关键词：
中图分类号：
作者姓名：
Hao Li;Qianru Guo;Qiufen Tu;Kaiqin Xiong;Wei Wang;Lei Lu;Wentai Zhang;Nan Huang;Zhilu Yang
作者机构：
Key Laboratory of Advanced Technology for Materials of Education Ministry,School of Materials Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China;Affiliated Dongguan People's Hospital,Southern Medical University,Dongguan 523059,China;State Key Laboratory of Molecular Engineering of Polymers(Fudan University),Shanghai 200438,China;Department of Cardiology,Zigong First People's Hospital,Zigong 643000,China;School&Hospital of Stomatology,Wenzhou Medical University,Wenzhou 325035,China;Sichuan Engineering Research Center for Biomimetic Synthesis of Natural Drugs,School of Life Science and Engineering,Southwest Jiaotong University,Chengdu 610031,China;Guangdong Provincial Key Laboratory of Shock and Microcirculation,Guangzhou 510080,China
文献出处：
引用格式：
[1]Hao Li;Qianru Guo;Qiufen Tu;Kaiqin Xiong;Wei Wang;Lei Lu;Wentai Zhang;Nan Huang;Zhilu Yang-.Nitric oxide-generating self-assembling peptide hydrogel coating for enhancing hemocompatibility of blood-contacting devices)[J].材料科学技术（英文版）,2022(36):106-114
A类：
stumbling,selenocys,RADA,nitrosothiols,RSNO,plasmatic
B类：
Nitric,oxide,generating,self,assembling,peptide,hydrogel,coating,enhancing,hemocompatibility,blood,contacting,devices,Thrombosis,major,block,clinical,application,Herein,quick,easy,surface,engineering,strategy,therapeutic,gas,nitric,generation,was,reported,realize,up,regulation,cyclic,guanosine,monophosphate,cGMP,improve,diverse,metal,materials,We,first,introduce,active,centre,teine,glutathione,peroxidase,GPx,obtaining,functionalized,Then,directly,coated,316L,stainless,steel,SS,catalytically,from,endogenous,generated,endows,platelet,behavior,reduction,coagulation,activation,complement,system,hence,improving,antithrombotic,ability,vitro,ex,vivo,Overall,our,provides,novel,solution,remove,obstacle,about,thrombosis
AB值：
0.584374
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
