典型文献
Research on Whitening Efficacy of Supramolecular Azelaic Acid in Zebrafish Models
文献摘要：
To discuss the inhibitory effect of supramolecular azelaic acid (SAZA) and azelaic acid (AZA) on melanin synthesis. The inhibition rate of tyrosinase activity was tested in vitro. Zebrafish embryos were exposed to SAZA and AZA in different proportions. The development of embryo melanin was observed and quantitatively analyzed. The experimental result showed that both AZA and SAZA had inhibitory effect on tyrosinase, with IC50 of 8.34 mmol/L for AZA and 6.56 mmol/L for SAZA. Zebrafish embryo is basically normally developed, with no obvious deformity. Both AZA and SAZA can inhibit the production of melanin, and the SAZA has a better effect in the same amount of experiment. In addition, AZA is able to inhibit the tyrosinase activity and melanin production in zebrafish embryos. The SAZA prepared by cyclodextrin inclusion has shown better water solubility and significantly improved compatibility.
文献关键词：
中图分类号：
作者姓名：
Peng Guanjie;Li Yangsi;He Shuilian;Wang Yaxin;Zhao Haishan
作者机构：
Guangzhou Tinglan Biotechnology Co.,Ltd.,China;Guangdong Provincial People's Hospital,China
文献出处：
引用格式：
[1]Peng Guanjie;Li Yangsi;He Shuilian;Wang Yaxin;Zhao Haishan-.Research on Whitening Efficacy of Supramolecular Azelaic Acid in Zebrafish Models)[J].日用化学品科学（英文）,2022(04):69-72
A类：
Whitening,Azelaic,azelaic,SAZA
B类：
Research,Efficacy,Supramolecular,Acid,Zebrafish,Models,To,discuss,inhibitory,effect,supramolecular,acid,melanin,synthesis,inhibition,rate,tyrosinase,activity,was,tested,vitro,embryos,were,exposed,different,proportions,development,observed,quantitatively,analyzed,experimental,result,showed,that,both,had,IC50,basically,normally,developed,obvious,deformity,Both,production,has,better,same,amount,In,addition,able,zebrafish,prepared,by,cyclodextrin,inclusion,shown,water,solubility,significantly,improved,compatibility
AB值：
0.441389
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
