典型文献
Could a phase model help to improve translational animal research?
文献摘要：
Background : Animal models are widely applied in medical research for different pur-poses. In particular, results from translational experiments may be used for subse-quent clinical development. However, transferability of these findings to the human organism is controversial. Among other factors, this may be traced back to a lack of clear differentiation of the evidence (explorative vs. confirmatory) provided by such experimental results. In general, inferential statistics (i.e. p values) should not be inter-preted in as confirmatory unless crucial methodological requirements are met. Methods : Therefore, we propose a phase model which reflects the well- established process of clinical research, and we discuss its potential to improve decision making in translational research. The model aims to clarify the reliability of results derived from animal models. Results : The phase model proposes subdividing translational, pre- clinical research into pilot, exploration, and confirmation phases. Experiments for which there is no valid estimation of the expected effect size are designated as pilot studies. Based on these data, experiments in subsequent phases may be planned using both appropriate design and statistical methods. Conclusion : Separating the entire process of translational animal research into three phases could contribute to improved transparency of the evidence derived from such experiments.
文献关键词：
中图分类号：
作者姓名：
Benjamin Mayer;Jan Tuckermann;Rainer Muche
作者机构：
Institute of Epidemiology and Medical Biometry , Ulm University , Ulm , Germany 2 Institute of Comparative Molecular Endocrinology , Ulm University , Ulm , Germany
文献出处：
引用格式：
[1]Benjamin Mayer;Jan Tuckermann;Rainer Muche-.Could a phase model help to improve translational animal research?)[J].动物模型与实验医学（英文）,2022(06):550-556
A类：
preted,subdividing
B类：
Could,help,translational,animal,research,Background,Animal,models,widely,applied,medical,pur,In,particular,results,from,experiments,may,be,used,clinical,development,However,transferability,these,findings,human,organism,controversial,Among,other,factors,this,traced,back,lack,clear,differentiation,evidence,explorative,confirmatory,provided,by,such,experimental,general,inferential,statistics,values,should,not,inter,unless,crucial,methodological,requirements,Methods,Therefore,which,reflects,well,established,process,discuss,its,potential,decision,making,aims,clarify,reliability,derived,Results,proposes,into,pilot,exploration,confirmation,phases,Experiments,there,valid,estimation,expected,effect,size,designated,studies,Based,data,subsequent,planned,using,both,appropriate,statistical,methods,Conclusion,Separating,entire,three,could,contribute,improved,transparency
AB值：
0.578875
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
