典型文献
Short-term exposure to ambient ozone associated with cardiac arrhythmias in healthy adults
文献摘要：
Objective:The exact biological mechanism whereby exposure to ambient ozone(O3)may contribute to clinical onset of cardiovascular events remains unclear.In this study,we aim to examine the impacts of O3 exposure on cardiac arrhythmias and potential pathways involved through autonomic dysfunction and myocardial injury.Methods:Seventy-three non-smoking healthy adults were followed with 4 repeated measurements of 24-hour ambulatory arrhythmias,heart rate variability,ST-segment deviation,and blood pressure(BP)in Beijing,China,2014-2016.Generalized additive mixed models coupled with distributed lag nonlinear models were constructed to evaluate the associations and potential interlinks between O3 exposure and outcome measurements.Results:During the study period,24-hour average concentrations of ambient O3 were 47.4 μg/m3(ranging from 1.0 to 165.9 μg/m3).Increased risks of premature ventricular contraction and ventricular tachycardia were associated with interquartile range increases in O3 exposure during the last 5 days before each participant's clinic visit,with relative risks of 2.14(95％confidence interval[CI]:1.95 to 2.32)and 5.47(95％CI:3.51 to 7.43),respectively.Mediation analyses further showed that sympathetic activation,parasympathetic inhibition,and elevated BP levels,as well as heightened risks of ST-segment depression could mediate up to 47.74％of the risks of arrhythmias attributable to O3 exposure.Conclusion:Our results suggest that short-term exposure to ambient O3 could prompt the genesis of arrhythmias partially through worsening autonomic function and myocardial burden.
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作者姓名：
Lingyan Liu;Yutong Zhu;Hongbing Xu;Yang Wang;Tong Wang;Qian Zhao;Yi Zhang;Jie Chen;Shengcong Liu;Tieci Yi;Rongshan Wu;Shuo Liu;Xiaoming Song;Jianping Li;Wei Huang
作者机构：
Department of Occupational and Environmental Health Sciences,School of Public Health,Peking University,Beijing 100191,China;Peking University Institute of Environmental Medicine,Peking University,Beijing 100191,China;Key Laboratory of Molecular Cardiovascular Sciences of Ministry of Education,Health Science Center,Peking University,Beijing 100191,China;Department of Prevention and Health Care,Hospital of Health Science Center,Peking University,Beijing 100191 China;Institute for Risk Assessment Sciences,University Medical Centre Utrecht,University of Utrecht,P.O.Box 80125,3508 TC Utrecht the Netherlands;Department of Cardiology,Peking University First Hospital,Beijing 100034,China
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引用格式：
[1]Lingyan Liu;Yutong Zhu;Hongbing Xu;Yang Wang;Tong Wang;Qian Zhao;Yi Zhang;Jie Chen;Shengcong Liu;Tieci Yi;Rongshan Wu;Shuo Liu;Xiaoming Song;Jianping Li;Wei Huang-.Short-term exposure to ambient ozone associated with cardiac arrhythmias in healthy adults)[J].全球健康杂志（英文）,2022(01):6-18
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0.620398
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