典型文献
Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging
文献摘要：
Fluorescence imaging is a noninvasive and dynamic real-time imaging technique;however,it exhibits poor spatial resolution in centimeter-deep tissues because biological tissues are highly scattering media for optical radiation.The recently developed ultrasound-controlled fluorescence(UCF)imaging is a novel imaging technique that can overcome this bottleneck.Previous studies suggest that the effective contrast agent and sensitive imaging system are the two pivotal factors for generating high-resolution UCF images ex vivo and/or in vivo.Here,this review highlights the recent advances(2015-2020)in the design and synthesis of contrast agents and the improvement of imaging systems to realize high-resolution UCF imaging of deep tissues.The imaging performances of various UCF systems,including the signal-to-noise ratio,imaging resolution,and imaging depth,are specifically discussed.In addition,the challenges and prospects are highlighted.With continuously increasing research interest in this field and emerging multidisciplinary applications,UCF imaging with higher spatial resolution and larger imaging depth may be developed shortly,which is expected to have a far-reaching impact on disease surveillance and/or therapy.
文献关键词：
中图分类号：
作者姓名：
Rui-Lin Liu;Ru-Qian Cai
作者机构：
School of Pharmacy,Xuzhou Medical University,Xuzhou,221004,China;Department of Pharmaceutical Analysis,School of Pharmacy,Xi'an Jiaotong University,Xi'an,710061,China
文献出处：
引用格式：
[1]Rui-Lin Liu;Ru-Qian Cai-.Recent advances in ultrasound-controlled fluorescence technology for deep tissue optical imaging)[J].药物分析学报（英文）,2022(04):530-540
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AB值：
0.570892
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