典型文献
Risk factors and outcomes for patients with pancreatic cancer undergoing surgical exploration without resection due to metastatic disease:A national cohort study
文献摘要：
Background:Unresectable disease is sometimes diagnosed during surgery in patients with pancreatic ductal adenocarcinoma(PDAC).This study aimed to identify preoperative risk factors for metastatic dis-ease diagnosed at surgical exploration and to investigate and compare survival in resected and non-resected patients.Methods:Patients were identified from the Swedish National Pancreatic and Periampullary Cancer Reg-istry 2010-2018.Predictors of metastatic disease were evaluated with a multivariable logistic regression model,and survival was evaluated with Kaplan-Meier estimates and log-rank tests.Results:In total,1938 patients with PDAC were scheduled for surgery.An unresectable situation was diagnosed intraoperatively in 399 patients(20.6％),including 234(12.1％)with metastasized disease.In-dependent risk factors for metastasis were involuntary weight loss(OR = 1.72;95％CI:1.27-2.33)and elevated carbohydrate antigen 19-9(CA19-9)(35-599 U/mL,OR = 1.79,95％CI:1.11-2.89;＞600 U/mL,OR = 3.24,95％CI:2.04-5.17).Overall survival was lower among patients with metastasized disease than that among patients with a resectable tumor(P＜0.001).Conclusions:Involuntary weight loss and an elevation of CA19-9 are preoperative risk factors for diag-nosing metastasized disease during surgical exploration.
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中图分类号：
作者姓名：
Emil Sahlstr?m;Paulina Bereza-Carlson;Johan Nilsson;Bobby Tingstedt;Bodil Andersson
作者机构：
Department of Clinical Sciences Lund,Surgery,Lund University,Sweden;Department of Surgery,Central Hospital Kristianstad,Sweden;Department of Translational Medicine,Cardiothoracic surgery and bioinformatics,Lund University,Sweden;Department of Thoracic and vascular surgery,Sk?ne University hospital,Lund,Sweden;Department of Surgery,Sk?ne University Hospital,Lund,Sweden
文献出处：
引用格式：
[1]Emil Sahlstr?m;Paulina Bereza-Carlson;Johan Nilsson;Bobby Tingstedt;Bodil Andersson-.Risk factors and outcomes for patients with pancreatic cancer undergoing surgical exploration without resection due to metastatic disease:A national cohort study)[J].国际肝胆胰疾病杂志(英文版),2022(03):279-284
A类：
Unresectable,Periampullary,metastasized,Involuntary,nosing
B类：
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AB值：
0.504122
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