Objective This study aimed to investigate whether cytokine profiles and virological markers might add value in monitoring the effects of peginterferon (PEG-IFN) therapy for hepatitis B e-antigen (HBeAg) positive chronic hepatitis B (CHB). Methods HBeAg positive patients with CHB were treated with PEG-IFN for 48 weeks. Clinical biochemical, and HBV serological indexes, as well as cytokines, were detected at baseline and every 12 weeks. Results A total of 116 patients with CHB were enrolled in this study; 100 patients completed the 48-week treatment and follow-up, of whom 38 achieved serum HBeAg disappearance, 25 achieved HBeAg seroconversion, 37 showed HBsAg decreases ≥ 1 log10 IU/mL, 9 showed HBsAg disappearance, and 8 became HBsAb positive. The cytokine levels at baseline and during treatment were similar between the HBeAg disappearance group and non-disappearance group. The disappearance of HBeAg was independently associated with HBeAg levels at weeks 12 and 24, and with the HBeAg decline at week 24 (P < 0.05). The HBsAg response was independently associated with HBsAg, the HBsAg decline, HBeAg, the HBeAg decline at week 12, and HBsAg at week 24 (P < 0.05). Conclusion There was no significant correlation between the response to interferon (IFN) and cytokines during PEG-IFN treatment. The changes in virological markers predicted the response to IFN after 48 weeks.

LI Ming Hui;SUN Fang Fang;CHEN Feng Xin;ZENG Zhan;LIN Yan Jie;BI Xiao Yue;YANG Liu;DENG Wen;JIANG Ting Ting;HUANG Rong Hai;YI Wei;XIE Yao

Department of Hepatology Division 2,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China;Department of Hepatology Division 2,Peking University Ditan Teaching Hospital,Beijing 100015,China;Capital Medical University,Beijing 100069,China;Department of Infectious Diseases,Capital Medical University,Beijing 100015,China;Department of General Surgery,Capital Medical University,Beijing 100015,China;Department of Gynecology and Obstetrics,Beijing Ditan Hospital,Capital Medical University,Beijing100015,China

生物医学与环境科学（英文版）

[1]LI Ming Hui;SUN Fang Fang;CHEN Feng Xin;ZENG Zhan;LIN Yan Jie;BI Xiao Yue;YANG Liu;DENG Wen;JIANG Ting Ting;HUANG Rong Hai;YI Wei;XIE Yao-.Cytokine Profiles and Virological Marker Monitoring during 48 Weeks Peginterferon Alfa Treatment for HBeAg-Positive Chronic Hepatitis B)[J].生物医学与环境科学（英文版）,2022(04):312-321

Virological,Peginterferon,peginterferon

Cytokine,Profiles,Marker,Monitoring,during,Weeks,Alfa,Treatment,HBeAg,Positive,Chronic,Hepatitis,Objective,This,study,aimed,investigate,whether,profiles,virological,markers,might,add,value,monitoring,effects,PEG,IFN,therapy,hepatitis,antigen,positive,chronic,CHB,Methods,patients,were,treated,weeks,Clinical,biochemical,HBV,serological,indexes,well,cytokines,detected,baseline,every,Results,total,enrolled,this,completed,treatment,follow,whom,achieved,serum,disappearance,seroconversion,showed,HBsAg,decreases,log10,IU,became,HBsAb,levels,similar,between,group,was,independently,associated,decline,response,Conclusion,There,significant,correlation,changes,predicted,after

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