典型文献
Asparaginase-associated pancreatitis in chemotherapy-treated pediatric patients: a five-year retrospective study
文献摘要：
Asparaginase (Asp) represents a key agent in induction remission for acute lymphoblastic leukemia (ALL) and certain subtypes of non-Hodgkin lymphoma (NHL). By catalyzing the hydrolysis of extracellular asparagine, thus depleting the level of plasma asparagine necessary for the growth of leukemic lymphoblasts, Asp can inhibit leukemic lymphoblast protein synthesis and lead to subsequent apoptosis with little myelosuppression.[1] This will achieve anti-leukemia efficacy, and promote the remission of leukemia.[2] A previous study showed that an Asp-containing regimen could significantly increase the event-free survival rate (71％ vs. 31％).[3] A previous study showed that those who completed the Asp regimen had a higher 5-year event-free survival rate (90％) than those who were unable to tolerate toxicity and quitted the treatment (73％).
文献关键词：
中图分类号：
作者姓名：
Chen-xi Liu;Yun-yu Zhang;Qiu-shi Yang;Shu-hong Shen;Jing Chen;Yan-jing Tang;Chang-cheng Chen;Zhuo Wang;Bi-ru Li;Juan Qian;Ying Wang;Wen-ting Hu;Bo-tao Ning
作者机构：
Department of Pediatric Hematology and Oncology,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China;Department of Pediatric Intensive Care Unit,Shanghai Children's Medical Center,School of Medicine,Shanghai Jiao Tong University,Shanghai 200127,China
文献出处：
引用格式：
[1]Chen-xi Liu;Yun-yu Zhang;Qiu-shi Yang;Shu-hong Shen;Jing Chen;Yan-jing Tang;Chang-cheng Chen;Zhuo Wang;Bi-ru Li;Juan Qian;Ying Wang;Wen-ting Hu;Bo-tao Ning-.Asparaginase-associated pancreatitis in chemotherapy-treated pediatric patients: a five-year retrospective study)[J].世界急诊医学杂志（英文）,2022(04):313-321
A类：
Asparaginase,lymphoblasts,lymphoblast,quitted
B类：
associated,pancreatitis,chemotherapy,treated,pediatric,patients,five,year,retrospective,study,represents,key,agent,induction,remission,acute,lymphoblastic,leukemia,ALL,certain,subtypes,Hodgkin,lymphoma,NHL,By,catalyzing,hydrolysis,extracellular,asparagine,thus,depleting,level,plasma,necessary,growth,leukemic,inhibit,protein,synthesis,lead,subsequent,apoptosis,little,myelosuppression,This,will,achieve,anti,efficacy,promote,previous,showed,that,containing,regimen,could,significantly,increase,event,free,survival,those,who,completed,had,higher,than,were,unable,tolerate,toxicity,treatment
AB值：
0.610788
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