典型文献
Essential role of MALAT1 in reducing traumatic brain injury
文献摘要：
As a highly evolutionary conserved long non-coding RNA, metastasis associated lung adenocarcinoma transcript 1 (MALAT1) was first demonstrated to be related to lung tumor metastasis by promoting angiogenesis. To investigate the role of MALAT1 in traumatic brain injury, we established mouse models of controlled cortical impact and cell models of oxygen-glucose deprivation to mimic traumatic brain injury in vitro and in vivo. The results revealed that MALAT1 silencing in vitro inhibited endothelial cell viability and tube formation but increased migration. In MALAT1-deficient mice, endothelial cell proliferation in the injured cortex, functional vessel density and cerebral blood flow were reduced. Bioinformatic analyses and RNA pull-down assays validated enhancer of zeste homolog 2 (EZH2) as a downstream factor of MALAT1 in endothelial cells. Jagged-1, the Notch homolog 1 (NOTCH1) agonist, reversed the MALAT1 deficiency-mediated impairment of angiogenesis. Taken together, our results suggest that MALAT1 controls the key processes of angiogenesis following traumatic brain injury in an EZH2/NOTCH1-dependent manner.
文献关键词：
中图分类号：
作者姓名：
Na Wu;Chong-Jie Cheng;Jian-Jun Zhong;Jun-Chi He;Zhao-Si Zhang;Zhi-Gang Wang;Xiao-Chuan Sun;Han Liu
作者机构：
Department of Neurosurgery,the First Affiliated Hospital of Chongqing Medical University,Chongqing,China;Department of Neurosurgery,Qilu Hospital of Shandong University(Qingdao Campus),Qingdao,Shandong Province,China
文献出处：
引用格式：
[1]Na Wu;Chong-Jie Cheng;Jian-Jun Zhong;Jun-Chi He;Zhao-Si Zhang;Zhi-Gang Wang;Xiao-Chuan Sun;Han Liu-.Essential role of MALAT1 in reducing traumatic brain injury)[J].中国神经再生研究（英文版）,2022(08):1776-1784
A类：
B类：
Essential,role,MALAT1,reducing,traumatic,brain,injury,highly,evolutionary,conserved,long,coding,metastasis,associated,lung,adenocarcinoma,transcript,was,first,demonstrated,related,tumor,by,promoting,angiogenesis,To,investigate,established,mouse,models,controlled,cortical,impact,oxygen,glucose,deprivation,mimic,vitro,vivo,results,revealed,that,silencing,inhibited,endothelial,viability,tube,formation,but,increased,migration,In,deficient,mice,proliferation,injured,cortex,functional,vessel,density,cerebral,blood,flow,were,reduced,Bioinformatic,analyses,pull,assays,validated,enhancer,zeste,homolog,EZH2,downstream,cells,Jagged,Notch,NOTCH1,agonist,reversed,deficiency,mediated,impairment,Taken,together,our,suggest,controls,key,processes,following,dependent,manner
AB值：
0.640575
相似文献
机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
