典型文献
Targeting the epigenome to treat neurodegenerative diseases or delay their onset: a perspective
文献摘要：
Epigenetic mechanisms regulate the chromatin structure and gene expression levels without changing the primary DNA sequence, and include DNA methylation and hydroxymethylation, post-translational modifications of histone tails and nucleosome positioning, as well as mechanisms mediated by long and short non-coding RNA molecules. These mechanisms are required for human development and cell differentiation, and are pivotal in differentiated cells for cellular functions, allowing a tight regulation of gene expression levels in response to environmental stimuli and cellular metabolic demands (Coppedè, 2021b).
文献关键词：
中图分类号：
作者姓名：
Fabio Coppedè
作者机构：
Department of Translational Research and of New Surgical and Medical Technologies, Interdepartmental Research Center Nutrafood"Nutraceuticals and Food for Health",University of Pisa,Pisa,Italy
文献出处：
引用格式：
[1]Fabio Coppedè-.Targeting the epigenome to treat neurodegenerative diseases or delay their onset: a perspective)[J].中国神经再生研究（英文版）,2022(08):1745-1747
A类：
hydroxymethylation,Copped,2021b
B类：
Targeting,epigenome,treat,neurodegenerative,diseases,delay,their,onset,perspective,Epigenetic,mechanisms,regulate,chromatin,structure,expression,levels,without,changing,primary,sequence,include,post,translational,modifications,histone,tails,nucleosome,positioning,well,mediated,by,long,short,coding,molecules,These,are,required,human,development,differentiation,pivotal,differentiated,cells,cellular,functions,allowing,tight,regulation,response,environmental,stimuli,metabolic,demands
AB值：
0.669997
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机标中图分类号，由域田数据科技根据网络公开资料自动分析生成，仅供学习研究参考。
