典型文献
Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer 's disease through reducing neuroinflammation and modulating intestinal microbiota
文献摘要：
Hydrogen exhibits the potential to treat Alzheimer's disease. Stereotactic injection has been previously used as an invasive method of administering active hydrogen, but this method has limitations in clinical practice. In this study, triple transgenic (3×Tg) Alzheimer's disease mice were treated with hydrogen-rich water for 7 months. The results showed that hydrogen-rich water prevented synaptic loss and neuronal death, inhibited senile plaques, and reduced hyperphosphorylated tau and neurofibrillary tangles in 3×Tg Alzheimer's disease mice. In addition, hydrogen-rich water improved brain energy metabolism disorders and intestinal flora imbalances and reduced inflammatory reactions. These findings suggest that hydrogen-rich water is an effective hydrogen donor that can treat Alzheimer's disease. This study was approved by the Animal Ethics and Welfare Committee of Shenzhen University, China (approval No. AEWC-20140615-002) on June 15, 2014.
文献关键词：
中图分类号：
作者姓名：
Yi-Tong Lin
作者机构：
College of Life Sciences and Oceanography,Guangdong Provincial Key Laboratory for Plant Epigenetics,Shenzhen University,Shenzhen,Guangdong Province,China;Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging,National-Regional Key Technology Engineering Laboratory for Medical Ultrasound,School of Biomedical Engineering,Health Science Center,Shenzhen University,Shenzhen,Guangdong Province,China;Shenzhen Bay Laboratory,Shenzhen,Guangdong Province,China
文献出处：
引用格式：
[1]Yi-Tong Lin-.Hydrogen-rich water ameliorates neuropathological impairments in a mouse model of Alzheimer 's disease through reducing neuroinflammation and modulating intestinal microbiota)[J].中国神经再生研究（英文版）,2022(02):409-417
A类：
neuropathological,AEWC
B类：
Hydrogen,rich,water,ameliorates,impairments,mouse,model,Alzheimer,disease,through,reducing,neuroinflammation,modulating,intestinal,microbiota,exhibits,potential,Stereotactic,injection,has,been,previously,used,invasive,method,administering,active,hydrogen,but,this,limitations,clinical,practice,In,study,triple,transgenic,Tg,mice,were,treated,months,results,showed,that,prevented,synaptic,loss,neuronal,death,inhibited,senile,plaques,reduced,hyperphosphorylated,tau,neurofibrillary,tangles,addition,improved,brain,energy,metabolism,disorders,flora,imbalances,inflammatory,reactions,These,findings,suggest,effective,donor,can,This,was,approved,by,Animal,Ethics,Welfare,Committee,Shenzhen,University,China,approval,No,June
AB值：
0.672058
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