The global outbreak of the coronavirus disease 2019 (COVID-19) led to the suspension of most treatments with assisted reproductive technique (ART). However, with the recent successful control of the pandemic in China, there is an urgent public need to resume full reproductive care. To determine whether the COVID-19 pandemic had any adverse effects on female fertility and the pregnancy outcomes of women undergoing ART, a systematic review and meta-analysis was conducted using the electronic Chinese and English databases. Dichotomous outcomes were summarized as prevalence, and odds ratios (ORs) and continuous outcomes as standardized mean difference (SMD) with 95％ confidence interval (CI). The risk of bias and subgroup analyses were assessed using Stata/SE 15.1 and R 4.1.2. The results showed that compared with women treated by ART in the pre-COVID-19 time frame, women undergoing ART after the COVID-19 pandemic exhibited no significant difference in the clinical pregnancy rate (OR 1.07, 95％CI 0.97 to 1.19;I2=0.0％), miscarriage rate (OR 0.95, 95％CI 0.79 to 1.14; I2=38.4％), embryo cryopreservation rate (OR 2.90, 95％ CI 0.17 to 48.13; I2=85.4％), and oocyte cryopreservation rate (OR 0.30, 95％CI 0.03 to 3.65;I2=81.6％). This review provided additional evidence for gynecologists to guide the management of women undergoing ART treatment during the COVID-19 pandemic timeframe.

Weihuan HU;Yuhang ZHU;Yan WU;Fangfang WANG;Fan QU

Women's Hospital,School of Medicine,Zhejiang University,Hangzhou 310006,China;The Second Hospital of Dalian Medical University,Dalian Medical University,Dalian 116000,China

浙江大学学报（英文版）（B辑：生物医学和生物技术）

[1]Weihuan HU;Yuhang ZHU;Yan WU;Fangfang WANG;Fan QU-.Impact of COVID-19 pandemic on the pregnancy outcomes of women undergoing assisted reproductive techniques (ARTs):a systematic review and meta-analysis)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(08):655-665,中插1-中插17

ARTs,Dichotomous,gynecologists

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