Autophagy is an intracellular degradation process that maintains cellular homeostasis. It is essential for protecting organisms from environmental stress. Autophagy can help the host to eliminate invading pathogens, including bacteria, viruses, fungi, and parasites. However, pathogens have evolved multiple strategies to interfere with autophagic signaling pathways or inhibit the fusion of autophagosomes with lysosomes to form autolysosomes. Moreover, host cell matrix degradation by different types of autophagy can be used for the proliferation and reproduction of pathogens. Thus, determining the roles and mechanisms of autophagy during pathogen infections will promote understanding of the mechanisms of pathogen?host interactions and provide new strategies for the treatment of infectious diseases.

Henan Key Laboratory of Immunology and Targeted Drugs,School of Laboratory Medicine,Xinxiang Medical University,Xinxiang 453003,China;Henan Collaborative Innovation Center of Molecular Diagnosis and Laboratory Medicine,Xinxiang Medical University,Xinxiang 453003,China

[1]Qianqian ZHENG;Liangwei DUAN;Yang ZHANG;Jiaoyang LI;Shiyu ZHANG;Hui WANG-.A dynamically evolving war between autophagy and pathogenic microorganisms)[J].浙江大学学报（英文版）（B辑：生物医学和生物技术）,2022(01):19-41

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