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典型文献
Genomic patterns of homozygosity and inbreeding depression in Murciano- Granadina goats
文献摘要:
Background:Inbreeding depression can adversely affect traits related to fitness, reproduction and productive performance. Although current research suggests that inbreeding levels are generally low in most goat breeds, the impact of inbreeding depression on phenotypes of economic interest has only been investigated in a few studies based on genealogical data. Results:We genotyped 1040 goats with the Goat SNP50 BeadChip. This information was used to estimate different molecular inbreeding coefficients and characterise runs of homozygosity and homozygosity patterns. We detected 38 genomic regions with increased homozygosity as well as 8 ROH hotspots mapping to chromosomes 1, 2, 4, 6, 14, 16 and 17. Eight hundred seventeen goats with available records for dairy traits were analysed to evaluate the potential consequences of inbreeding depression on milk phenotypes. Four regions on chromosomes 8 and 25 were significantly associated with inbreeding depression for the natural logarithm of the somatic cell count. Notably, these regions contain several genes related with immunity, such as SYK, IL27, CCL19 and CCL21. Moreover, one region on chromosome 2 was significantly associated with inbreeding depression for milk yield. Conclusions:Although genomic inbreeding levels are low in Murciano-Granadina goats, significant evidence of inbreeding depression for the logarithm of the somatic cell count, a phenotype closely associated with udder health and milk yield, have been detected in this population. Minimising inbreeding would be expected to augment economic gain by increasing milk yield and reducing the incidence of mastitis, which is one of the main causes of dairy goat culling.
文献关键词:
作者姓名:
María Gracia Luigi-Sierra;Almudena Fernández;Amparo Martínez;Dailu Guan;Juan Vicente Delgado;Javier FernándezÁlvarez;Vincenzo Landi;Francesc Xavier Such;Jordi Jordana;María Saura;Marcel Amills
作者机构:
Centre for Research in Agricultural Genomics(CRAG),CSIC-IRTA-UAB-UB, Universitat Autònoma de Barcelona,08193 Bellaterra,Spain;Departamento de Mejora Genética Animal,INIA,Carretera de la Coru?a km 7,5,28040 Madrid,Spain;Departamento de Genética,Universidad de Córdoba,14071 Córdoba,Spain;Department of Veterinary Medicine,University of Bari'Aldo Moro",62 per Casamassima km.3,70010 Valenzano,SP,Italy;Group of Research in Ruminants(G2R),Department of Animal and Food Science, Universitat Autònoma de Barcelona(UAB),Bellaterra,Barcelona,Spain;Departament de Ciència Animal i dels Aliments,Facultat de Veterinària, Universitat Autònoma de Barcelona,08193 Bellaterra,Spain
引用格式:
[1]María Gracia Luigi-Sierra;Almudena Fernández;Amparo Martínez;Dailu Guan;Juan Vicente Delgado;Javier FernándezÁlvarez;Vincenzo Landi;Francesc Xavier Such;Jordi Jordana;María Saura;Marcel Amills-.Genomic patterns of homozygosity and inbreeding depression in Murciano- Granadina goats)[J].畜牧与生物技术杂志(英文版),2022(03):721-734
A类:
Murciano,Granadina,Inbreeding,genealogical,SNP50,IL27,udder,Minimising,culling
B类:
Genomic,patterns,homozygosity,inbreeding,depression,goats,Background,adversely,affect,traits,related,fitness,reproduction,productive,performance,Although,current,research,suggests,that,levels,are,generally,low,most,breeds,impact,phenotypes,economic,interest,has,only,been,investigated,few,studies,data,Results,We,genotyped,Goat,BeadChip,This,information,was,used,estimate,different,molecular,coefficients,characterise,runs,detected,genomic,regions,increased,well,ROH,hotspots,mapping,chromosomes,Eight,hundred,seventeen,available,records,dairy,were,analysed,evaluate,potential,consequences,milk,Four,significantly,associated,natural,logarithm,somatic,cell,count,Notably,these,contain,several,genes,immunity,such,SYK,CCL19,CCL21,Moreover,one,yield,Conclusions,evidence,closely,health,have,this,population,would,expected,augment,gain,by,increasing,reducing,incidence,mastitis,which,main,causes
AB值:
0.490178
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