Antimicrobials have been widely used to prevent and treat infectious diseases and promote growth in food-production animals. However, the occurrence of antimicrobial resistance poses a huge threat to public and animal health, especially in less developed countries where food-producing animals often intermingle with humans. To limit the spread of antimicrobial resistance from food-production animals to humans and the environment, it is essential to have a comprehensive knowledge of the role of the resistome in antimicrobial resistance (AMR), The resistome refers to the collection of all antimicrobial resistance genes associated with microbiota in a given environment. The dense microbiota in the digestive tract is known to harbour one of the most diverse resistomes in nature. Studies of the resistome in the digestive tract of humans and animals are increasing exponentially as a result of advancements in next-generation sequencing and the expansion of bioinformatic resources/tools to identify and describe the resistome. In this review, we outline the various tools/bioinformatic pipelines currently available to characterize and understand the nature of the intestinal resistome of swine, poultry, and ruminants. We then propose future research directions including analysis of resistome using long-read sequencing, investigation in the role of mobile genetic elements in the expression, function and transmission of AMR. This review outlines the current knowledge and approaches to studying the resistome in food-producing animals and sheds light on future strategies to reduce antimicrobial usage and control the spread of AMR both within and from livestock production systems.

Tao Ma;Tim A.McAllister;Le Luo Guan

Key laboratory of Feed Biotechnology of the Ministry of Agriculture,Institute of Feed Research,Chinese Academy of Agricultural Sciences,Beijing 100081,China;Department of Agricultural,Food and Nutritional Science,University of Alberta,T6G2P5,Edmonton,AB,Canada;Lethbridge Research and Development Centre,Lethbridge,AB T1J 4P4,Canada

畜牧与生物技术杂志（英文版）

[1]Tao Ma;Tim A.McAllister;Le Luo Guan-.A review of the resistome within the digestive tract of livestock)[J].畜牧与生物技术杂志（英文版）,2022(03):642-661

intermingle

review,within,digestive,tract,livestock,Antimicrobials,have,been,widely,used,prevent,treat,infectious,diseases,promote,growth,food,production,animals,However,occurrence,antimicrobial,resistance,poses,huge,threat,public,health,especially,less,developed,countries,where,producing,often,humans,To,limit,spread,from,environment,essential,comprehensive,knowledge,role,AMR,refers,collection,genes,associated,microbiota,given,dense,known,harbour,most,diverse,resistomes,nature,Studies,are,increasing,exponentially,result,advancements,next,generation,sequencing,expansion,bioinformatic,resources,tools,identify,describe,In,this,various,pipelines,currently,available,characterize,understand,intestinal,swine,poultry,ruminants,We,then,propose,future,research,directions,including,analysis,using,long,investigation,mobile,genetic,elements,expression,function,transmission,This,outlines,approaches,studying,sheds,light,strategies,reduce,usage,control,both,systems

0.520855