典型文献
Development of an integrated process for the production of high-purityγ-aminobutyric acid from fermentation broth
文献摘要：
γ-Aminobutyric acid(GABA),a natural non-protein amino acid,plays an irreplaceable role in regulating the life activities of organisms.Nowadays,the separation and purification of food-grade GABA from fer-mentation broth is still a great challenge.This research utilized monosodium glutamate as a substrate for the production of high-purity GABA via an integrated process incorporating fermentation,purification,and crystallization.Firstly,147 g·L-1 GABA with a yield of 99.8％was achieved through fed-batch fermen-tation by Lactobacillus brevis CE701.Secondly,three integrated purification methods by ethanol precipi-tation were compared,and crude GABA with a purity of 89.85％was obtained by the optimized method.Thirdly,GABA crystals with a purity of 98.69％and a yield of 60％were further obtained through a designed crystallization process.Furthermore,the GABA industrial production process model was estab-lished by Superproper Designer V10 software,and material balance and economic analysis were carried out.Ethanol used in the process was recovered with a recovery of 98.79％through Aspen simulated extractive distillation.Then the fixed investment(equipment purchase and installation costs)for an annual production of 80t GABA will be about 833000 USD;the total annual production cost(raw material cost and utility cost)will be about 641000 USD.The annual sale of GABA may be at the range of 2400000-4000000 USD and the payback period will be about 1-2 year.This integrated process provides a potential way for the industrial-scale production of food-grade GABA.
文献关键词：
中图分类号：
作者姓名：
Zhaofeng Zhang;Juanjuan Ding;Min Wu;Bochao Liu;Huiwen Song;Shengping You;Wei Qi;Rongxin Su;Zhimin He
作者机构：
Chemical Engineering Research Center,School of Chemical Engineering and Technology,Tianjin University,Tianjin 300072,China;Henan Julong Biological Engineering Co.,Ltd,China;Tianjin Key Laboratory of Membrane Science and Desalination Technology,Tianjin University,Tianjin 300072,China;State Key Laboratory of Chemical Engineering,Tianjin University,Tianjin 300072,China;Collaborative Innovation Center of Chemical Science and Engineering(Tianjin),Tianjin 300072,China
文献出处：
引用格式：
[1]Zhaofeng Zhang;Juanjuan Ding;Min Wu;Bochao Liu;Huiwen Song;Shengping You;Wei Qi;Rongxin Su;Zhimin He-.Development of an integrated process for the production of high-purityγ-aminobutyric acid from fermentation broth)[J].中国化学工程学报（英文版）,2022(10):361-368
A类：
CE701,Superproper
B类：
Development,integrated,process,production,high,purity,aminobutyric,acid,from,fermentation,broth,Aminobutyric,GABA,natural,protein,plays,irreplaceable,role,regulating,life,activities,organisms,Nowadays,separation,purification,food,grade,great,challenge,This,research,utilized,monosodium,glutamate,substrate,via,incorporating,crystallization,Firstly,yield,was,achieved,through,fed,batch,by,Lactobacillus,brevis,Secondly,three,methods,ethanol,precipi,were,compared,crude,obtained,optimized,Thirdly,crystals,further,designed,Furthermore,industrial,model,estab,lished,Designer,V10,software,material,balance,economic,analysis,carried,Ethanol,used,recovered,recovery,Aspen,simulated,extractive,distillation,Then,fixed,investment,equipment,purchase,installation,costs,annual,80t,will,be,about,USD,total,raw,utility,sale,may,range,payback,period,year,provides,potential,way,scale
AB值：
0.536407
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